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008 151211s2016 sz | s |||| 0|eng d
020 |a9783319263366|9978-3-319-26336-6
024 7 |a10.1007/978-3-319-26336-6|2doi
041 |aeng
049 |aTürk Tarih Kurumu Kütüphanesi
050 4|aQ124.6-127.2
072 7|aPDX|2bicssc
072 7|aSCI034000|2bisacsh
072 7|aPDX|2thema
082 04|a509|223
090 |aDK/2733
100 1 |aWall, Wilson John.|eauthor.|4aut|4http://id.loc.gov/vocabulary/relators/aut
245 14|aThe Search for Human Chromosomes|h[electronic resource] :|bA History of Discovery /|cby Wilson John Wall.
250 |a1st ed. 2016.
264 1|aCham :|bSpringer International Publishing :|bImprint: Springer,|c2016.
300 |aVII, 179 p. 48 illus., 28 illus. in color.|bonline resource.
336 |atext|btxt|2rdacontent
337 |acomputer|bc|2rdamedia
338 |aonline resource|bcr|2rdacarrier
347 |atext file|bPDF|2rda
505 0 |aIntroduction -- Background to the Hunt for the Human Chromosome Number -- Microscopes and Stains: The Rise of Technology -- Mendel and Genetics -- Chromosomes as the Carriers of Heredity -- Difficulties of Chromosome Handling and Access to Material -- The Implications of DNA Structure -- Tissue Culture and the Cell Cycle: The Answer is Revealed -- The Flowering of Clinical Genetics -- Sex and Chromosomes -- What we Know, What we Don’t and Where This may Lead us -- Appendix A: Rough Guide to Chromosome Structure -- Appendix B: People in the Text -- Glossary.
520 |aThis book is a broadly historical account of a remarkable and very exciting scientific story–the search for the number of human chromosomes. It covers the processes and people, culminating in the realization that discovering the number of human chromosomes brought as much benefit as unraveling the genetic code itself.  With the exception of red blood cells, which have no nucleus and therefore no DNA, and sex cells, humans have 46 chromosomes in every single cell. Not only do chromosomes carry all of the genes that code our inheritance, they also carry them in a specific order. It is essential that the number and structure of chromosomes remains intact, in order to pass on the correct amount of DNA to succeeding generations and for the cells to survive. Knowing the number of human chromosomes has provided a vital diagnostic tool in the prenatal diagnosis of genetic disorders, and the search for this number and developing an understanding of what it means are the focus of this book.
650 0|aScience|xHistory.
650 0|aMedical genetics.
650 0|aCytology.
650 14|aHistory of Science.
650 24|aMedical Genetics.
650 24|aCell Biology.
773 0 |tSpringer Nature eBook
776 08|iPrinted edition:|z9783319263342
776 08|iPrinted edition:|z9783319263359
776 08|iPrinted edition:|z9783319799346
856 40|uhttps://doi.org/10.1007/978-3-319-26336-6
912 |aZDB-2-HTY
912 |aZDB-2-SXH
950 |aHistory (SpringerNature-41172)
950 |aHistory (R0) (SpringerNature-43722)